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Article

N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review.

American journal of epidemiology - 1 May 2000

Brockton N, Little J, Sharp L, Cotton S C

Abstract excerpt

The two expressed genes coding for N-acetyltransferase (NAT) activity, NAT1 and NAT2, are located on chromosome 8 at 8p21.3-23.1 and are polymorphic. Both enzymes are capable of N-acetylation, O-acetylation, and N,O-acetylation and are implicated in the activation and detoxification of known carcinogens. Single base-pair substitutions in NAT2 tend to occur in combination with other substitutions within the gene....

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Source

Identifiers

PMID: 10791558
DOI: 10.1093/oxfordjournals.aje.a010289

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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