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Article

Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma.

BMC medical genetics - 30 May 2007

Mahid Suhal S, Colliver Daniel W, Crawford Nigel P S, Martini Benjamin D, Doll Mark A, Hein David W, Cobbs Gary A, Petras Robert E, Galandiuk Susan

Abstract excerpt

BACKGROUND: N-acetyltransferase 1 (NAT1) and 2 (NAT2) are polymorphic isoenzymes responsible for the metabolism of numerous drugs and carcinogens. Acetylation catalyzed by NAT1 and NAT2 are important in metabolic activation of arylamines to electrophilic intermediates that initiate carcinogenesis. Inflammatory bowel diseases (IBD) consist of Crohn's disease (CD) and ulcerative colitis (UC), both are associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17537267
DOI: 10.1186/1471-2350-8-28
PMCID: PMC1903350

Genes

NAT2
NAT1

Provenance

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