Article
Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland.
Pharmacogenetics - 1 Feb 1997
Syvänen A C, Tilgmann C, Rinne J, Ulmanen I
Abstract excerpt
The catechol-O-methyltransferase (COMT) gene occurs as two polymorphic alleles, which code for a high activity thermostable and low activity thermolabile form of the enzyme. We devised a fast solid-phase minisequencing assay for genotyping the COMT gene at nucleotide position 544 encoding amino a...
Topics
- Catechol O-Methyltransferase
- DNA
- DNA Primers
- Enzyme Stability
- Erythrocytes
- Female
- Finland
- Gene Frequency
- Genetic Variation
- Genotype
- Hot Temperature
- Humans
- Male
- Parkinson Disease
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Reference Values