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Article

Catechol O-methyltransferase pharmacogenomics: human liver genotype-phenotype correlation and proximal promoter studies.

Pharmacogenetics and genomics - 1 Aug 2009

Zhang Jianping, Ji Yuan, Moon Irene, Pelleymounter Linda L, Ezequel Salavaggione Oreste, Wu Yanhong, Jenkins Gregory D, Batzler Anthony J, Schaid Daniel J, Weinshilboum Richard M

Abstract excerpt

OBJECTIVES: Catechol O-methyltransferase (COMT) is expressed as both soluble (S) and membrane-bound (MB) isoforms, with S-COMT predominantly expressed in the liver. A common nonsynonymous single nucleotide polymorphism (SNP), 472G > A (108/158Val > Met, S/MB), has been associated with variation in levels of COMT enzyme activity and thermal stability. We set out to test the hypothesis that additional COMT...

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Identifiers

PMID: 19641441
DOI: 10.1097/FPC.0b013e32832c15c6
PMCID: PMC3052748

Genes

COMT

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