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Article

Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer.

Cancer research - 15 Mar 1995

Sekido Y, Pass H I, Bader S, Mew D J, Christman M F, Gazdar A F, Minna J D

Abstract excerpt

We have found 16 of 28 small cell lung cancers, 17 of 31 non-small cell lung cancers, 2 of 3 carcinoids, and 12 of 14 mesotheliomas that had chromosome 22 cytogenetic abnormalities. To determine whether the neurofibromatosis type 2 (NF2) gene located on chromosome 22 participates in the oncogenesis of these malignancies, we studied DNAs from lung cancer cell lines and mesotheliomas using Southern blot analysis...

Topics

Base Sequence
Chromosomes, Human, Pair 22
DNA-Binding Proteins
Gene Deletion
Genes, Neurofibromatosis 2
Genes, Tumor Suppressor
Humans
Lung Neoplasms
Mesothelioma
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription Factors

Tumor Cells, Cultured

WT1 Proteins

Source

Identifiers

PMID: 7882313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7882313-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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