Article
Quantitative analysis of neurofibromatosis type 2 gene transcripts in meningiomas supports the concept of distinct molecular variants.
Laboratory investigation; a journal of technical methods and pathology - 1 Dec 1997
Wellenreuther R, Waha A, Vogel Y, Lenartz D, Schramm J, Wiestler O D, von Deimling A
Abstract excerpt
Meningiomas frequently show mutational inactivation of the neurofibromatosis type 2 tumor suppressor gene (NF2 gene). In a previous study, mutations were preferentially observed in the fibroblastic and transitional subtypes (75%), whereas the meningothelial variant was significantly less affected...
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