Article
Amyloid beta neurotoxicity in the cholinergic but not in the serotonergic phenotype of RN46A cells.
Brain research. Molecular brain research - 15 Jun 1998
Olesen O F, Dagø L, Mikkelsen J D
Abstract excerpt
Neuropathological examination of brains from AD patients has documented that distinct areas and nuclei are differently affected by the disease. It is unknown as to what extent the neurochemical phenotype plays a role in this process, but particularly acetylcholine (Ach) neurons in the basal forebrain are lost during the progress of the disease. The exact molecular mechanism by which the neuronal death is induced...
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