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Article

Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 7 May 2016

Tajeddinn Walid, Persson Torbjörn, Calvo-Garrido Javier, Seed Ahmed Mohammed, Maioli Silvia, Vijayaraghavan Swetha, Kazokoglu Mehmet Selim, Parrado-Fernández Cristina, Yoshitake Takashi, Kehr Jan, Francis Paul, Winblad Bengt, Höglund Kina, Cedazo-Minguez Angel, Aarsland Dag

Abstract excerpt

Serotonin (5-HT) plays a central role in the integrity of different brain functions. The 5-HT homeostasis is regulated by many factors, including serotonin transporter (SERT), monoamine oxidase enzyme (MAO), and several 5-HT receptors, including the 5-HT1B. There is little knowledge how the dynamics of this system is affected by the amyloid-β (Aβ) burden of Alzheimer's disease (AD) pathology. SH-SY5Y...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27163814
DOI: 10.3233/JAD-160046

Genes

MAOA
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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