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Article

Aβ Mediated Diminution of MTT Reduction—An Artefact of Single Cell Culture?

18 Sept 2008

Abstract excerpt

The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide (MTT) reduction assay is a frequently used and easily reproducible method to measure beta-amyloid (Abeta) toxicity in different types of single cell culture. To our knowledge, the influence of Abeta on MTT reduction has never been tested in more complex tissue. Initially, we reproduced the disturbed MTT reduction in neuron and astroglia primary cell...

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PMID: 18800168
DOI: 10.1371/journal.pone.0003236

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