Article
CNTF induces raphe neuronal precursors to switch from a serotonergic to a cholinergic phenotype in vitro.
Molecular and cellular neurosciences - 1 Mar 1996
Rudge J S, Eaton M J, Mather P, Lindsay R M, Whittemore S R
Abstract excerpt
Ciliary neurotrophic factor (CNTF) is a multifunctional cytokine that mediates survival and differentiation of neurons as well as many other cell types. In this study, CNTF and leukemia inhibitory factor (LIF) reduced the apparent number of primary serotonergic neurons in E14 raphe culture by 90%...
Topics
- Acetylcholinesterase
- Animals
- Calcium Channels
- Cell Count
- Cell Differentiation
- Cell Survival
- Cells, Cultured
- Cholinergic Fibers
- Chromatography, High Pressure Liquid
- Ciliary Neurotrophic Factor
- Immunohistochemistry
- Mice
- Mice, Knockout
- Nerve Growth Factors
- Nerve Tissue Proteins
- Neurons
- Phenotype
- Raphe Nuclei