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Article

Dibutyryl cyclic AMP induces differentiation of human neuroblastoma SH-SY5Y cells into a noradrenergic phenotype.

Neuroscience letters - 10 Oct 2008

Kume Toshiaki, Kawato Yuka, Osakada Fumitaka, Izumi Yasuhiko, Katsuki Hiroshi, Nakagawa Takayuki, Kaneko Shuji, Niidome Tetsuhiro, Takada-Takatori Yuki, Akaike Akinori

Abstract excerpt

Dibutyryl cyclic AMP (dbcAMP) and retinoic acid (RA) have been demonstrated to be the inducers of morphological differentiation in SH-SY5Y cells, a human catecholaminergic neuroblastoma cell line. However, it remains unclear whether morphologically differentiated SH-SY5Y cells by these compounds acquire catecholaminergic properties. We focused on the alteration of tyrosine hydroxylase (TH) expression and...

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Identifiers

PMID: 18691633
DOI: 10.1016/j.neulet.2008.07.079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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