Article
The cholinergic neuronal phenotype in Alzheimer's disease.
Metabolic brain disease - 1 Mar 2000
Blusztajn J K, Berse B
Abstract excerpt
The synthesis, storage and release of acetylcholine (ACh) requires the expression of several specialized proteins, including choline acetyltransferase (ChAT) and the vesicular ACh transporter (VAChT). The VAChT gene is located within the first intron of the ChAT gene. This unique genomic organization permits coordinated activation of expression of the two genes by extracellular factors. Much less is known about...
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