Article
Extended sequence context shapes mutational bias in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 2026
Jago Matthew J, Green Rowan, Czernuszka Maisie R, Denisov Stepan, Krašovec Rok, Knight Christopher G, Lagator Mato
Abstract excerpt
Understanding how sequence context influences the likelihood of mutation at a given genomic locus is critical for deciphering evolutionary processes. It is well established that the immediately adjacent bases influence mutation rates, but the role of more distal bases remains poorly understood. Here, we analyze over 100,000 mutations from 32 Escherichia coli mutation accumulation experiments, encompassing strains...
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