Article
'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain.
Oncogene - 18 Jun 1998
Lányi A, Deb D, Seymour R C, Ludes-Meyers J H, Subler M A, Deb S
Abstract excerpt
Tumor-derived p53 mutants can transcriptionally activate a number of promoters of genes involved in cellular proliferation. For this transactivation, mutant p53 does not use the wild-type p53 DNA-binding site, suggesting a mechanism of transactivation that is independent of direct DNA binding. He...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Biopolymers
- Cell Line
- DNA
- ErbB Receptors
- Humans
- Mice
- Mutation
- Phenotype
- Proliferating Cell Nuclear Antigen
- Promoter Regions, Genetic
- Protein Binding
- Sequence Deletion
- Transcriptional Activation
- Tumor Suppressor Protein p53