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Article

'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain.

Oncogene - 18 Jun 1998

Lányi A, Deb D, Seymour R C, Ludes-Meyers J H, Subler M A, Deb S

Abstract excerpt

Tumor-derived p53 mutants can transcriptionally activate a number of promoters of genes involved in cellular proliferation. For this transactivation, mutant p53 does not use the wild-type p53 DNA-binding site, suggesting a mechanism of transactivation that is independent of direct DNA binding. Here we describe our analysis of the domain requirements for mutant p53 to transactivate promoters of the human epidermal...

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Source

Identifiers

PMID: 9671396
DOI: 10.1038/sj.onc.1201857

Genes

EGFR
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain.PMID 9671396Read ↗

Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants.Semantic proximity Read ↗

The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth.Semantic proximity Read ↗

Gain of function mutations in p53.Semantic proximity Read ↗

Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo.Semantic proximity Read ↗

Characterization of functional domains necessary for mutant p53 gain of function.Semantic proximity Read ↗

Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription.Semantic proximity Read ↗

The requirement of the carboxyl terminus of p53 for DNA binding and transcriptional activation depends on the specific p53 binding DNA element.Semantic proximity Read ↗

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.Semantic proximity Read ↗

Sequence-specific transcriptional activation is essential for growth suppression by p53.Semantic proximity Read ↗

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.Semantic proximity Read ↗

Transcriptional Activation of the Human Epidermal Growth Factor Receptor Promoter by Human p53Semantic proximity Read ↗

Identification of a novel p53 functional domain that is necessary for efficient growth suppressionSemantic proximity Read ↗

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