The requirement of the carboxyl terminus of p53 for DNA binding and transcriptional activation depends on the specific p53 binding DNA element.

Article

The requirement of the carboxyl terminus of p53 for DNA binding and transcriptional activation depends on the specific p53 binding DNA element.

Oncogene - 1 Sept 1994

Zhang W, Guo X Y, Deisseroth A B

Abstract excerpt

The p53 protein specifically binds DNA sequences and activates transcription. In this study, we investigated the requirement of the carboxyl (C)- or amino (N)-terminal domain of p53 for the binding and transactivation of two DNA elements, p53CON and the ribosomal gene cluster (RGC). Three human p...

Topics

Base Sequence
DNA
Humans
Molecular Sequence Data
Mutation
Structure-Activity Relationship
Transcriptional Activation
Tumor Cells, Cultured
Tumor Suppressor Protein p53

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