Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants.

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Article

Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants.

Oncogene - 15 Jun 1995

Lin J, Teresky A K, Levine A J

Abstract excerpt

Some mutant forms of the p53 protein have been shown to gain new functions that are not shared by the wild-type p53 protein; (1) mutant p53 proteins can transcriptionally transactivate the multi-drug resistance gene-1 (MDR-1) and (2) when expressed in non-tumorigenic cells with no endogenous p53...

Topics

Animals
Cell Line
Chloramphenicol O-Acetyltransferase
Codon
DNA, Complementary
Genes, p53
Humans
Leucine
Mice
Mice, Nude
Mutation
Neoplasms, Experimental
Phenotype
Transcriptional Activation
Tryptophan
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 7784087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7784087-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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