Article
Sequence-specific transcriptional activation is essential for growth suppression by p53.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1994
Pietenpol J A, Tokino T, Thiagalingam S, el-Deiry W S, Kinzler K W, Vogelstein B
Abstract excerpt
Although several biochemical features of p53 have been described, their relationship to tumor suppression remains uncertain. We have compared the ability of p53-derived proteins to act as sequence-specific transcriptional (SST) activators with their ability to suppress tumor cell growth, using an...
Topics
- Base Sequence
- Cell Division
- Cloning, Molecular
- DNA
- DNA-Binding Proteins
- Fungal Proteins
- Herpes Simplex Virus Protein Vmw65
- Humans
- Molecular Sequence Data
- Mutation
- Protein Conformation