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Article

Sequence-specific transcriptional activation is essential for growth suppression by p53.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1994

Pietenpol J A, Tokino T, Thiagalingam S, el-Deiry W S, Kinzler K W, Vogelstein B

Abstract excerpt

Although several biochemical features of p53 have been described, their relationship to tumor suppression remains uncertain. We have compared the ability of p53-derived proteins to act as sequence-specific transcriptional (SST) activators with their ability to suppress tumor cell growth, using an improved growth-suppression assay. Both naturally occurring and in vitro derived mutations that abrogated the SST...

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Identifiers

PMID: 8134338
DOI: 10.1073/pnas.91.6.1998
PMCID: PMC43296

Genes

SST

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Research trail→

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Sequence-specific transcriptional activation is essential for growth suppression by p53.PMID 8134338Read ↗

Functions of the p53 protein in growth regulation and tumor suppression.Semantic proximity Read ↗

Discerning the function of p53 by examining its molecular interactions.Semantic proximity Read ↗

Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes.Semantic proximity Read ↗

Transcription regulation by mutant p53.Semantic proximity Read ↗

Transcriptional activities of mutant p53: when mutations are more than a loss.Semantic proximity Read ↗

Transcriptional activation by p53 correlates with suppression of growth but not transformation.Semantic proximity Read ↗

Identification of a novel p53 functional domain that is necessary for efficient growth suppressionSemantic proximity Read ↗

Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo.Semantic proximity Read ↗

Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53.Semantic proximity Read ↗

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages.Semantic proximity Read ↗

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.Semantic proximity Read ↗

The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth.Semantic proximity Read ↗

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