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Article

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

The EMBO journal - 15 Dec 1993

Halazonetis T D, Kandil A N

Abstract excerpt

p53 is a conformationally flexible sequence-specific DNA binding protein mutated in many human tumors. To understand why the mutant p53 proteins associated with human tumors fail to bind DNA, we mapped the DNA binding domain of wild-type p53 and examined its regulation by changes in the protein conformation. Using site-directed mutagenesis, residues 90-286 of mouse p53 were shown to form the sequence-specific DNA...

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Identifiers

PMID: 8262048
DOI: 10.1002/j.1460-2075.1993.tb06199.x
PMCID: PMC413766

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Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.PMID 8262048Read ↗

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