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Article

Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription.

Oncogene - 1 Jul 1993

Miller C W, Chumakov A, Said J, Chen D L, Aslo A, Koeffler H P

Abstract excerpt

Accumulating evidence supports the hypothesis that tumor-suppressor p53 can act as a transcriptional activator. Insertion of high-affinity p53 DNA binding sites upstream of a promoter yields a p53-responsive vector. Chimeric proteins fusing p53 and the GAL4 DNA-binding domain demonstrate the presence of a transcriptional activating domain in the N-terminus of p53. GAL4-p53 chimeras constructed using naturally...

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Source

Identifiers

PMID: 8510927

Genes

CAT
GAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription.PMID 8510927Read ↗

Mutant p53 proteins behave in a dominant, negative fashion in vivo.Semantic proximity Read ↗

Disruption of functions of wild-type p53 by hetero-oligomerization.Semantic proximity Read ↗

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.Semantic proximity Read ↗

Re-engineered p53 chimera with enhanced homo-oligomerization that maintains tumor suppressor activity.Semantic proximity Read ↗

The Ashkenazi-Centric G334R Variant of TP53 is Severely Impaired for Transactivation but Retains Tumor Suppressor Function in a Mouse Model.Semantic proximity Read ↗

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.Semantic proximity Read ↗

Cancer-derived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart.Semantic proximity Read ↗

Mammalian p53 can function as a transcription factor in yeastSemantic proximity Read ↗

'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain.Semantic proximity Read ↗

Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutantsSemantic proximity Read ↗

The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth.Semantic proximity Read ↗

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay.Semantic proximity Read ↗

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