Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription.

Article

Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription.

Oncogene - 1 Jul 1993

Miller C W, Chumakov A, Said J, Chen D L, Aslo A, Koeffler H P

Abstract excerpt

Accumulating evidence supports the hypothesis that tumor-suppressor p53 can act as a transcriptional activator. Insertion of high-affinity p53 DNA binding sites upstream of a promoter yields a p53-responsive vector. Chimeric proteins fusing p53 and the GAL4 DNA-binding domain demonstrate the pres...

Topics

Alleles
Animals
CHO Cells
Cricetinae
Humans
Mutation
Oligopeptides
Precipitin Tests
Recombinant Fusion Proteins
Structure-Activity Relationship
Transcriptional Activation
Tumor Suppressor Protein p53

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