Article
A chicken c-Rel-estrogen receptor chimeric protein shows conditional nuclear localization, DNA binding, transformation and transcriptional activation.
Oncogene - 18 Jun 1998
Zurovec M, Petrenko O, Roll R, Enrietto P J
Abstract excerpt
In this report, we characterize the biological and biochemical properties of a conditional protein containing chicken c-Rel fused to the hormone-binding domain of the human estrogen receptor. This chimeric c-RelER protein causes estrogen-dependent, but otherwise c-Rel-specific, transformation of...
Topics
- Animals
- Base Sequence
- Cell Nucleus
- Cell Transformation, Neoplastic
- Chick Embryo
- Clone Cells
- DNA
- DNA-Binding Proteins
- Fibroblasts
- Gene Expression
- HeLa Cells
- Humans
- NF-kappa B
- Phenotype
- Protein Binding
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-rel
- Quail