Article
IkB-alpha-specific transcript regulation by the C-terminal end of c-Rel.
FEBS letters - 3 Jan 2005
Iwai Kazuyuki, Lee Byung Rho, Hashiguchi Masaaki, Fukushima Atsuki, Iwashima Makio
Abstract excerpt
The NF-kB family transcription factor c-Rel is a critical molecule for inducing expression of cytokine genes by T cells. Here, we report that a deletion of the C-terminal end, similar to the deletion in the highly oncogenic chicken v-Rel gene, renders c-Rel hyperactive toward cytokine gene promoters. At the same time, this mutation dramatically reduced c-Rel activity in induction of IkB-alpha mRNA expression....
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