Article
Mutations in the DNA-binding and dimerization domains of v-Rel are responsible for altered kappa B DNA-binding complexes in transformed cells.
Journal of virology - 1 Jun 1995
Hrdlicková R, Nehyba J, Bose H R
Abstract excerpt
The c-rel proto-oncogene encodes a member of the Rel/NF-kappa B family of transcription factors. The oncogenic viral form, v-rel, transduced by avian reticuloendotheliosis virus T, induces lymphoid tumors. v-Rel transformation may be mediated directly by binding of v-Rel to cognate DNA sites, res...
Topics
- Animals
- Base Sequence
- Biopolymers
- Cell Line, Transformed
- Cell Nucleus
- Chickens
- DNA-Binding Proteins
- Molecular Sequence Data
- Mutation
- NF-kappa B
- Oligodeoxyribonucleotides
- Oncogene Proteins v-rel
- Protein Binding
- Retroviridae Proteins, Oncogenic