Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel.

doi:10.1128/mcb.12.9.4067-4075.1992

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Article

Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel.

Molecular and cellular biology - 1 Sept 1992

Tan T H, Huang G P, Sica A, Ghosh P, Young H A, Longo D L, Rice N R

Abstract excerpt

The cis-acting control elements of the interleukin-2 receptor alpha-chain (IL-2R alpha) gene contain a potent kappa B-like enhancer whose activity can be induced by various mitogenic stimuli. Recent cloning of the p50 and p65 subunits of the kappa B-binding protein NF-kappa B complex revealed a striking sequence homology of these proteins with the c-rel proto-oncogene product (c-Rel). On the basis of this...

Topics

Base Sequence
Binding, Competitive
Cloning, Molecular
DNA
Deoxyribonuclease I
Enhancer Elements, Genetic
Escherichia coli
Gene Expression Regulation
Humans
Lymphocyte Activation
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Promoter Regions, Genetic

Proto-Oncogene Mas

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-rel

Receptors, Interleukin-2

Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1508203
DOI: 10.1128/mcb.12.9.4067-4075.1992
PMCID: PMC360300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1508203-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel.PMID 1508203Read ↗

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