Selection and analysis of rare second-site suppressors of Drosophila RNA polymerase II mutations.

doi:10.1007/s004380050756

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Selection and analysis of rare second-site suppressors of Drosophila RNA polymerase II mutations.

Molecular & general genetics : MGG - 1 Jun 1998

Krasnoselskaya I, Huang J, Jones T, Dezan C, Mortin M A

Abstract excerpt

We used a mutagenesis and selection procedure in Drosophila melanogaster to recover rare allele-specific suppressor mutations. More than 11 million flies mutant for one of five recessive-lethal mutations in the two largest subunits of RNA polymerase II were selected for additional mutations that restored viability. Forty-one suppressor mutations were recovered. At least 16 are extragenic, identifying a minimum of...

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Selection and analysis of rare second-site suppressors of Drosophila RNA polymerase II mutations.

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Selection and analysis of rare second-site suppressors of Drosophila RNA polymerase II mutations.

Abstract excerpt

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