Selection and analysis of rare second-site suppressors of Drosophila RNA polymerase II mutations.

doi:10.1007/s004380050756

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Article

Selection and analysis of rare second-site suppressors of Drosophila RNA polymerase II mutations.

Molecular & general genetics : MGG - 1 Jun 1998

Krasnoselskaya I, Huang J, Jones T, Dezan C, Mortin M A

Abstract excerpt

We used a mutagenesis and selection procedure in Drosophila melanogaster to recover rare allele-specific suppressor mutations. More than 11 million flies mutant for one of five recessive-lethal mutations in the two largest subunits of RNA polymerase II were selected for additional mutations that...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
DNA Mutational Analysis
Drosophila melanogaster
Molecular Sequence Data
Mutagenesis
Point Mutation
RNA Polymerase II
Suppression, Genetic

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