Article
Use of second-site suppressor mutations in Drosophila to identify components of the transcriptional machinery.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990
Mortin M A
Abstract excerpt
Isolation of second-site suppressor mutations provides a powerful method for identifying (i) genes that encode proteins that interact and (ii) domains within the interacting proteins that contact each other. Flies conditionally lethal because they carry mutations in the largest subunit of RNA pol...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Drosophila
- Genes
- Genes, Lethal
- Genotype
- Heat-Shock Proteins
- Macromolecular Substances
- Mutation
- Promoter Regions, Genetic
- RNA Polymerase II
- Suppression, Genetic
- Transcription, Genetic