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Article

pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2000

Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais M L, Sardet C

Abstract excerpt

The retinoblastoma protein pRB is involved in the transcriptional control of genes essential for cell cycle progression and differentiation. pRB interacts with different transcription factors and thereby modulates their activity by sequestration, corepression, or activation. We report that pRB, but not p107 and p130, binds to and facilitates repression by p120(E4F), a ubiquitously expressed GLI-Kruppel-related...

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Share to Adenovirus E1A Proteins
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10869426
DOI: 10.1073/pnas.130198397
PMCID: PMC16614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.PMID 10869426Read ↗

Activity of the Retinoblastoma Family Proteins, pRB, p107, and p130, during Cellular Proliferation and DifferentiationSemantic proximity Read ↗

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Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.Semantic proximity Read ↗

Conserved RB functions in development and tumor suppressionSemantic proximity Read ↗

A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice.Semantic proximity Read ↗

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E2F and the molecular mechanisms of early cell-cycle control.Semantic proximity Read ↗

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