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Article

E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop.

Molecular and cellular biology - 1 Jan 2007

Timmers Cynthia, Sharma Nidhi, Opavsky Rene, Maiti Baidehi, Wu Lizhao, Wu Juan, Orringer Daniel, Trikha Prashant, Saavedra Harold I, Leone Gustavo

Abstract excerpt

E2F-mediated control of gene expression is believed to have an essential role in the control of cellular proliferation. Using a conditional gene-targeting approach, we show that the targeted disruption of the entire E2F activator subclass composed of E2f1, E2f2, and E2f3 in mouse embryonic fibrob...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17167174
DOI: 10.1128/MCB.02147-05
PMCID: PMC1800646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17167174-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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