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Article

E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop.

Molecular and cellular biology - 1 Jan 2007

Timmers Cynthia, Sharma Nidhi, Opavsky Rene, Maiti Baidehi, Wu Lizhao, Wu Juan, Orringer Daniel, Trikha Prashant, Saavedra Harold I, Leone Gustavo

Abstract excerpt

E2F-mediated control of gene expression is believed to have an essential role in the control of cellular proliferation. Using a conditional gene-targeting approach, we show that the targeted disruption of the entire E2F activator subclass composed of E2f1, E2f2, and E2f3 in mouse embryonic fibroblasts leads to the activation of p53 and the induction of p53 target genes, including p21(CIP1). Consequently,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17167174
DOI: 10.1128/MCB.02147-05
PMCID: PMC1800646

Genes

E2F1
E2F2
E2F3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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