Article
High colony forming capacity of primary cultured hepatocytes as a dominant trait in hepatocarcinogenesis-susceptible and resistant mouse strains.
Carcinogenesis - 1 Jun 1998
Yoshie M, Nishimori H, Lee G H, Ogawa K
Abstract excerpt
When hepatocytes isolated from mouse liver are cultivated in vitro, a small fraction of cells can survive, forming colonies, while most cells die within a few weeks. We compared the colony forming capacity of hepatocytes in three mouse strains; two strains susceptible for hepatocarcinogenesis, C3H/HeJ (C3) and DBA/2J mice (D2), and one resistant strain, C57BL/6J mice (B6). The colony forming capacity was about...
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