Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of the stages of initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat.

Carcinogenesis - 1 May 1992

Dragan Y P, Pitot H C

Abstract excerpt

Differences in the distribution of phenotypic alterations in initiated and promoted cell populations reflect both the dose and the action of the specific initiating agent, as well as the mechanism of action of the promoting agent. The use of multiple phenotypic markers to characterize AHF should allow further experimentation on the characteristics of promoting agents in hepatocarcinogenesis, especially their...

Topics

Animals
Carcinogens
Cell Transformation, Neoplastic
Diet
Gene Expression Regulation, Neoplastic
Liver Neoplasms, Experimental
Mutation
Phenotype
Rats

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1586986
DOI: 10.1093/carcin/13.5.739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1586986-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of the stages of initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat.PMID 1586986Read ↗

Biochemical markers associated with the stages of promotion and progression during hepatocarcinogenesis in the rat.Semantic proximity Read ↗

Quantitation of Multistage Carcinogenesis in Rat LiverSemantic proximity Read ↗

Comparison of hepatocyte phenotypes at the glutathione transferase and albumin loci in Sprague-Dawley and Nagase analbuminemic rats and F1 progeny after initiation and promotion.Semantic proximity Read ↗

Definition of stages during hepatocarcinogenesis in the rat: potential application to the evaluation of initiating and promoting agents in the environment.Semantic proximity Read ↗

Role of cell proliferation at early stages of hepatocarcinogenesis.Semantic proximity Read ↗

Promotion of hepatocarcinogenesis in humans and animal modelsSemantic proximity Read ↗

Genetic instability occurs sooner than expected: promotion, progression and clonality during hepatocarcinogenesis in the rat.Semantic proximity Read ↗

Similarities and differences in hepatitis B and C virus induced hepatocarcinogenesisSemantic proximity Read ↗

The effect of the format of administration and the total dose of phenobarbital on altered hepatic foci following initiation in female rats with diethylnitrosamine.Semantic proximity Read ↗

Short-term fasting and the reversal of the stage of promotion in rat hepatocarcinogenesis: role of cell replication, apoptosis, and gene expression.Semantic proximity Read ↗

Initiated rat hepatocytes in primary culture: a novel tool to study alterations in growth control during the first stage of carcinogenesis.Semantic proximity Read ↗

Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.