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Article

Low p38 MAPK and JNK activation in cultured hepatocytes of DRH rats; a strain highly resistant to hepatocarcinogenesis.

Molecular carcinogenesis - 1 Sept 2007

Honmo Satoshi, Ozaki Atsuko, Yamamoto Masahiro, Hashimoto Norikazu, Miyakoshi Masaaki, Tanaka Hiroki, Yoshie Masumi, Tamakawa Susumu, Tokusashi Yoshihiko, Yaginuma Yuji, Kasai Shinichi, Ogawa Katsuhiro

Abstract excerpt

DRH rats are a hepatocarcinogenesis-resistant strain isolated from hepatocarcinogenesis-sensitive Donryu rats, and the liver of DRH shows less histological damage and fewer/smaller neoplastic hepatic lesions by the treatment with hepatocarcinogens. To investigate the mechanism of the resistance, the properties of hepatocytes of DRH and Donryu were compared. In primary culture, DRH hepatocytes exhibited higher...

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Source

Identifiers

PMID: 17546627
DOI: 10.1002/mc.20304

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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