Article
Rapid detection of K-ras gene mutations in canine lung cancer using single-strand conformational polymorphism analysis.
Carcinogenesis - 1 Jun 1998
Griffey S M, Kraegel S A, Madewell B R
Abstract excerpt
A total of 126 spontaneous lung tumors from pet dogs were examined for K-ras mutations within exon 1 and exon 2 using a non-radioisotope single-strand conformational polymorphism analysis (SSCP) detection method on PCR products. Mutations were confirmed by direct DNA sequencing. Tumors were classified as adenomas (9), bronchioloalveolar carcinomas (59), adenocarcinomas (30), adenosquamous carcinomas (16),...
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