Rapid detection of K-ras gene mutations in canine lung cancer using single-strand conformational polymorphism analysis.

doi:10.1093/carcin/19.6.959

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Article

Rapid detection of K-ras gene mutations in canine lung cancer using single-strand conformational polymorphism analysis.

Carcinogenesis - 1 Jun 1998

Griffey S M, Kraegel S A, Madewell B R

Abstract excerpt

A total of 126 spontaneous lung tumors from pet dogs were examined for K-ras mutations within exon 1 and exon 2 using a non-radioisotope single-strand conformational polymorphism analysis (SSCP) detection method on PCR products. Mutations were confirmed by direct DNA sequencing. Tumors were class...

Topics

Animals
Base Sequence
DNA Primers
Dog Diseases
Dogs
Genes, ras
Lung Neoplasms
Mutation
Polymorphism, Single-Stranded Conformational

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