Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma.

Article

Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma.

Cancer research - 1 Apr 1995

Mills N E, Fishman C L, Rom W N, Dubin N, Jacobson D R

Abstract excerpt

Reported estimates of ras mutation prevalence in lung adenocarcinoma of 15-24% may be underestimates because of the insensitivity of the assays used. We have devised a rapid, non-radioactive assay for ras mutations, which detects 1 mutant allele/10(3) normal alleles and have used it to study DNA...

Topics

Adenocarcinoma
Base Sequence
Codon
DNA Mutational Analysis
DNA, Neoplasm
Genes, ras
Humans
Lung Neoplasms
Molecular Sequence Data
Mutation
Sensitivity and Specificity

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