Article
c-N-ras is activated infrequently in canine malignant lymphoma.
Toxicologic pathology - 1 Jan 1993
Edwards M D, Pazzi K A, Gumerlock P H, Madewell B R
Abstract excerpt
Activated c-N-ras alleles have been detected in human lymphoma specimens. The aim of the present study was to determine the frequency of c-N-ras mutational activation in canine malignant lymphoma. DNA was isolated from 28 canine malignant lymphoma specimens collected from 28 separate dogs and examined for c-N-ras mutations by polymerase chain reaction amplification and direct sequencing. The tumors were naturally...
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