Article
K-ras activation in non-small cell lung cancer in the dog.
Cancer research - 1 Sept 1992
Kraegel S A, Gumerlock P H, Dungworth D L, Oreffo V I, Madewell B R
Abstract excerpt
To investigate the role of K-ras mutations in canine non-small cell lung cancer, we first determined the nucleotide sequence of the normal canine K-ras gene and then examined 21 canine lung tumors for activating K-ras mutations. Canine K-ras was analyzed by direct sequencing of polymerase chain r...
Topics
- Animals
- Base Sequence
- Carcinoma
- Carcinoma, Non-Small-Cell Lung
- DNA, Neoplasm
- Dogs
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Proto-Oncogene Proteins p21(ras)
- RNA, Messenger
- RNA, Neoplasm