Article
K-ras activation in non-small cell lung cancer in the dog.
Cancer research - 1 Sept 1992
Kraegel S A, Gumerlock P H, Dungworth D L, Oreffo V I, Madewell B R
Abstract excerpt
To investigate the role of K-ras mutations in canine non-small cell lung cancer, we first determined the nucleotide sequence of the normal canine K-ras gene and then examined 21 canine lung tumors for activating K-ras mutations. Canine K-ras was analyzed by direct sequencing of polymerase chain reaction products generated with oligonucleotide primers derived from the human K-ras sequence. Four nucleotide...
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