Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2004

Pelosi Giuseppe, Scarpa Aldo, Manzotti Michela, Veronesi Giulia, Spaggiari Lorenzo, Fraggetta Filippo, Nappi Oscar, Benini Elvira, Pasini Felice, Antonello Davide, Iannucci Antonio, Maisonneuve Patrick, Viale Giuseppe

Abstract excerpt

We investigated 27 pleomorphic carcinomas of the lung for exon 1 K-ras gene mutations using polymerase chain reaction-single-strand conformation polymophism analysis and direct sequencing. All pleomorphic carcinomas were biphasic, that is, composed of an adeno-, squamous- or large-cell-carcinomatous component associated with a spindle- and/or giant-cell component. Of 27 cases, six (22%) showed K-ras codon 12...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Large Cell
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Clone Cells

Share to Genes, ras

Share to Keratins

Share to Polymorphism, Single-Stranded Conformational

Share to Survival Analysis

Share to Vimentin

Source

Identifiers

PMID: 14990969
DOI: 10.1038/modpathol.3800058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung.PMID 14990969Read ↗

Review Article: Pulmonary Sarcomatoid Carcinomas: A Practical OverviewSemantic proximity Read ↗

Molecular profiles of EGFR, K-ras, c-met, and FGFR in pulmonary pleomorphic carcinoma, a rare lung malignancy.Semantic proximity Read ↗

EGFR and p53 status of pulmonary pleomorphic carcinoma: implications for EGFR tyrosine kinase inhibitors therapy of an aggressive lung malignancy.Semantic proximity Read ↗

BRONCHIOLOALVEOLAR LUNG CARCINOMAS: K-ras MUTATIONS ARE CONSTANT EVENTS IN THE MUCINOUS SUBTYPESemantic proximity Read ↗

Bronchioloalveolar adenocarcinoma of lung: monoclonal origin for multifocal disease.Semantic proximity Read ↗

Clinical significance of ras oncogene activation in human lung cancer.Semantic proximity Read ↗

Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma.Semantic proximity Read ↗

Clonality and heterogeneity of pulmonary blastoma from the viewpoint of genetic alterations: a case report.Semantic proximity Read ↗

Analysis of K-ras gene mutations in malignant and nonmalignant endobronchial tissue obtained by fiberoptic bronchoscopy.Semantic proximity Read ↗

Detection of K-ras mutations of bronchoalveolar lavage fluid cells aids the diagnosis of lung cancer in small pulmonary lesions.Semantic proximity Read ↗

Detection of K-ras mutations in lung carcinomas: relationship to prognosis.Semantic proximity Read ↗

Rapid detection of K-ras gene mutations in canine lung cancer using single-strand conformational polymorphism analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.