Article
Comparison of the open-close kinetics of the cloned inward rectifier K+ channel IRK1 and its point mutant (Q140E) in the pore region.
Receptors & channels - 1 Jan 1998
Guo L, Kubo Y
Abstract excerpt
To test whether a single amino-acid residue at the center of pore region can dictate the difference of open-close kinetics in a steady-state at hyperpolarized potentials among members of the inward K+ channel family, the Q140E mutant of the inward rectifier K+ channel (IRK1) was made and its gati...
Topics
- Amino Acid Sequence
- Animals
- Cloning, Molecular
- Ion Channel Gating
- Kinetics
- Molecular Sequence Data
- Mutation
- Porins
- Potassium Channels
- Sequence Alignment