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Article

Comparison of the open-close kinetics of the cloned inward rectifier K+ channel IRK1 and its point mutant (Q140E) in the pore region.

Receptors & channels - 1 Jan 1998

Guo L, Kubo Y

Abstract excerpt

To test whether a single amino-acid residue at the center of pore region can dictate the difference of open-close kinetics in a steady-state at hyperpolarized potentials among members of the inward K+ channel family, the Q140E mutant of the inward rectifier K+ channel (IRK1) was made and its gating properties were compared with those of IRK1 wild type (Wt) in Xenopus oocytes. The distinct differences were...

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Source

Identifiers

PMID: 9666520

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