C-terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1.

doi:10.1002/j.1460-2075.1995.tb00240.x

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Article

C-terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1.

The EMBO journal - 15 Nov 1995

Taglialatela M, Ficker E, Wible B A, Brown A M

Abstract excerpt

Critical loci for ion conduction in inward rectifier K+ channels are only now being discovered. The C-terminal region of IRK1 plays a crucial role in Mg2+i blockade and single-channel K+ conductance. A negatively charged aspartate in the putative second transmembrane domain (position 172) is esse...

Topics

Amino Acid Sequence
Animals
Magnesium
Molecular Sequence Data
Mutation
Oocytes
Polyamines
Potassium Channel Blockers
Potassium Channels
Potassium Channels, Inwardly Rectifying
Signal Transduction
Structure-Activity Relationship
Xenopus

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