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Article

C-terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1.

The EMBO journal - 15 Nov 1995

Taglialatela M, Ficker E, Wible B A, Brown A M

Abstract excerpt

Critical loci for ion conduction in inward rectifier K+ channels are only now being discovered. The C-terminal region of IRK1 plays a crucial role in Mg2+i blockade and single-channel K+ conductance. A negatively charged aspartate in the putative second transmembrane domain (position 172) is essential for time-dependent block by the cytoplasmic polyamines spermine and spermidine. We have now localized the...

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Identifiers

PMID: 8521810
DOI: 10.1002/j.1460-2075.1995.tb00240.x
PMCID: PMC394667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

C-terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1.PMID 8521810Read ↗

Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel.Semantic proximity Read ↗

The role of the cytoplasmic pore in inward rectification of Kir2.1 channels.Semantic proximity Read ↗

Determination of the subunit stoichiometry of an inwardly rectifying potassium channel.Semantic proximity Read ↗

Interaction mechanisms between polyamines and IRK1 inward rectifier K+ channels.Semantic proximity Read ↗

Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics.Semantic proximity Read ↗

An inner-pore mutation (F315D) promotes intracellular Mg2+ block and inward rectification of BK channels.Semantic proximity Read ↗

Electrostatics in the cytoplasmic pore produce intrinsic inward rectification in kir2.1 channels.Semantic proximity Read ↗

Inward rectification by polyamines in mouse Kir2.1 channels: synergy between blocking components.Semantic proximity Read ↗

Inward rectification and implications for cardiac excitability.Semantic proximity Read ↗

Effects of extracellular cations and mutations in the pore region on the inward rectifier K+ channel IRK1.Semantic proximity Read ↗

Charges in the cytoplasmic pore control intrinsic inward rectification and single-channel properties in Kir1.1 and Kir2.1 channels.Semantic proximity Read ↗

Pharmacological implications of inward rectifier K+ channels regulation by cytoplasmic polyamines.Semantic proximity Read ↗

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