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Article

Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel.

The Journal of physiology - 15 Mar 2001

Kubo Y, Murata Y

Abstract excerpt

1. The rectification property of the inward rectifier K+ channel is chiefly due to the block of outward current by cytoplasmic Mg2+ and polyamines. In the cloned inward rectifier K+ channel Kir2.1 (IRK1), Asp172 in the second transmembrane region (M2) and Glu224 in the putative cytoplasmic region after M2 are reported to be critical for the sensitivity to these blockers. However, the difference in the inward...

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Identifiers

PMID: 11251047
DOI: 10.1111/j.1469-7793.2001.0645h.x
PMCID: PMC2278501

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Source receipt: pubmed, retrieved 7 Sept 2026.

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