Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Electrostatics in the cytoplasmic pore produce intrinsic inward rectification in kir2.1 channels.

The Journal of general physiology - 1 Dec 2005

Yeh Shih-Hao, Chang Hsueh-Kai, Shieh Ru-Chi

Abstract excerpt

Inward rectifier K+ channels are important in regulating membrane excitability in many cell types. The physiological functions of these channels are related to their unique inward rectification, which has been attributed to voltage-dependent block. Here, we show that inward rectification can also be induced by neutral and positively charged residues at site 224 in the internal vestibule of tetrameric Kir2.1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoplasm
Share to Electrophysiology
Share to Ion Transport

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oocytes

Share to Potassium Channels, Inwardly Rectifying

Share to Spermine

Share to Static Electricity

Share to Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 16316974
DOI: 10.1085/jgp.200509367
PMCID: PMC2266598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Electrostatics in the cytoplasmic pore produce intrinsic inward rectification in kir2.1 channels.PMID 16316974Read ↗

Charges in the cytoplasmic pore control intrinsic inward rectification and single-channel properties in Kir1.1 and Kir2.1 channels.Semantic proximity Read ↗

Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel.Semantic proximity Read ↗

Voltage-dependent gating and block by internal spermine of the murine inwardly rectifying K+ channel, Kir2.1.Semantic proximity Read ↗

An inner-pore mutation (F315D) promotes intracellular Mg2+ block and inward rectification of BK channels.Semantic proximity Read ↗

Mechanism for attenuated outward conductance induced by mutations in the cytoplasmic pore of Kir2.1 channels.Semantic proximity Read ↗

Gating of the kir2.1 channel at the bundle crossing region by intracellular spermine and other cations.Semantic proximity Read ↗

Intrinsic electrostatic potential in the BK channel pore: role in determining single channel conductance and block.Semantic proximity Read ↗

The bundle crossing region is responsible for the inwardly rectifying internal spermine block of the Kir2.1 channel.Semantic proximity Read ↗

The role of the cytoplasmic pore in inward rectification of Kir2.1 channels.Semantic proximity Read ↗

A ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation.Semantic proximity Read ↗

Voltage-dependent inhibition of outward Kir2.1 currents by extracellular spermine.Semantic proximity Read ↗

C-terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.