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Article

Voltage-dependent gating and block by internal spermine of the murine inwardly rectifying K+ channel, Kir2.1.

The Journal of physiology - 15 Apr 2003

Matsuda Hiroko, Oishi Keiko, Omori Koichiro

Abstract excerpt

The mechanism of inward rectification was investigated by recording single-channel currents through an inwardly rectifying K+ channel (Kir2.1). cDNA encoding a wild-type (WT) channel, a mutant replacing Asp 172 with Asn (D172N), and a tandem tetramer WT-(D172N)2-WT, was transfected into COS-1 cells using the liposome method, and after 48-72 h single-channel currents were recorded in the inside-out configuration...

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Source

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Identifiers

PMID: 12640008
DOI: 10.1113/jphysiol.2003.038844
PMCID: PMC2342863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Voltage-dependent gating and block by internal spermine of the murine inwardly rectifying K+ channel, Kir2.1.PMID 12640008Read ↗

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