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Article

Mutations in the pore region of ROMK enhance Ba2+ block.

The American journal of physiology - 1 Dec 1996

Zhou H, Chepilko S, Schütt W, Choe H, Palmer L G, Sackin H

Abstract excerpt

The sequence of the hydrophobic "P" (pore) region of a K(+)-selective channel from the kidney (ROMK2) was altered to match that of the closely related inward rectifier (IRK1) channel by changing two amino acids, leucine (L) 117 and valine (V) 121, to isoleucine (I) and threonine (T), respectively. The mutant channel expressed in Xenopus laevis oocytes had an apparent inhibition constant at zero voltage [Ki(0)] in...

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Source

Identifiers

PMID: 8997197
DOI: 10.1152/ajpcell.1996.271.6.C1949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the pore region of ROMK enhance Ba2+ block.PMID 8997197Read ↗

Biophysical effects of pore mutations of ROMK1.Semantic proximity Read ↗

Identification of a site involved in the block by extracellular Mg(2+) and Ba(2+) as well as permeation of K(+) in the Kir2.1 K(+) channel.Semantic proximity Read ↗

An inner-pore mutation (F315D) promotes intracellular Mg2+ block and inward rectification of BK channels.Semantic proximity Read ↗

Amino acid substitutions in the pore of the Ca(V)1.2 calcium channel reduce barium currents without affecting calcium currents.Semantic proximity Read ↗

K+ binding in the G-loop and water cavity facilitates Ba2+ movement in the Kir2.1 channel.Semantic proximity Read ↗

A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating.Semantic proximity Read ↗

KirBac1.1: it's an inward rectifying potassium channel.Semantic proximity Read ↗

A Bartter's syndrome mutation of ROMK1 exerts dominant negative effects on K(+) conductance.Semantic proximity Read ↗

The role of a single aspartate residue in ionic selectivity and block of a murine inward rectifier K+ channel Kir2.1.Semantic proximity Read ↗

Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect.Semantic proximity Read ↗

Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel.Semantic proximity Read ↗

Ionic interactions of Ba2+ blockades in the MthK K+ channel.Semantic proximity Read ↗

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