Mutations in the pore region of ROMK enhance Ba2+ block.

doi:10.1152/ajpcell.1996.271.6.C1949

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Article

Mutations in the pore region of ROMK enhance Ba2+ block.

The American journal of physiology - 1 Dec 1996

Zhou H, Chepilko S, Schütt W, Choe H, Palmer L G, Sackin H

Abstract excerpt

The sequence of the hydrophobic "P" (pore) region of a K(+)-selective channel from the kidney (ROMK2) was altered to match that of the closely related inward rectifier (IRK1) channel by changing two amino acids, leucine (L) 117 and valine (V) 121, to isoleucine (I) and threonine (T), respectively...

Topics

Amino Acid Sequence
Animals
Barium
Gene Expression
Ion Transport
Molecular Sequence Data
Mutation
Potassium Channels
Potassium Channels, Inwardly Rectifying
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