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Article

Effects of extracellular cations and mutations in the pore region on the inward rectifier K+ channel IRK1.

Receptors & channels - 1 Jan 1996

Kubo Y

Abstract excerpt

It is known that the rectification property of the inward rectifier K+ channel, IRK1, is caused by a block of outward current by cytoplasmic Mg2+ and polyamines, and that the voltage dependence of rectification shifts according to the equilibrium potential of K+. Here it is shown that extracellular K+ (K+ o) but not intracellular K+ (K+ i) affects the activation kinetics of IRK1. A mutant in which the conserved...

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PMID: 8865359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Effects of extracellular cations and mutations in the pore region on the inward rectifier K+ channel IRK1.PMID 8865359Read ↗

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C-terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1.Semantic proximity Read ↗

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Charges in the cytoplasmic pore control intrinsic inward rectification and single-channel properties in Kir1.1 and Kir2.1 channels.Semantic proximity Read ↗

K+ binding sites and interactions between permeating K+ ions at the external pore mouth of an inward rectifier K+ channel (Kir2.1).Semantic proximity Read ↗

An inner-pore mutation (F315D) promotes intracellular Mg2+ block and inward rectification of BK channels.Semantic proximity Read ↗

Pharmacological implications of inward rectifier K+ channels regulation by cytoplasmic polyamines.Semantic proximity Read ↗

Inward rectification and implications for cardiac excitability.Semantic proximity Read ↗

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Interaction mechanisms between polyamines and IRK1 inward rectifier K+ channels.Semantic proximity Read ↗

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