Effects of extracellular cations and mutations in the pore region on the inward rectifier K+ channel IRK1.

Article

Effects of extracellular cations and mutations in the pore region on the inward rectifier K+ channel IRK1.

Receptors & channels - 1 Jan 1996

Kubo Y

Abstract excerpt

It is known that the rectification property of the inward rectifier K+ channel, IRK1, is caused by a block of outward current by cytoplasmic Mg2+ and polyamines, and that the voltage dependence of rectification shifts according to the equilibrium potential of K+. Here it is shown that extracellul...

Topics

Amino Acid Sequence
Cations
Cell Line
Extracellular Space
Humans
Ion Channel Gating
Membrane Potentials
Molecular Sequence Data
Mutation
Patch-Clamp Techniques
Potassium Channels

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.