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Article

Isolation and characterization of mutated mitochondrial GTP:AMP phosphotransferase.

Journal of molecular biology - 17 Jul 1998

Yamada M, Sugahara M, Hishitani Y, Nobumoto M, Nakazawa A

Abstract excerpt

GTP:AMP phosphotransferase (adenylate kinase isozyme 3, AK3) mutants were obtained by using the ability of AK3 to complement a temperature-sensitive mutation of Escherichia coli adenylate kinase (AKe). Five mutants, P16L, G19S, G91D, G91S, and P93L, had mutation sites located at two loops that are involved in substrate binding of the enzyme. P16L and G19S bearing changes at the first loop showed reduced affinity...

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PMID: 9665856
DOI: 10.1006/jmbi.1998.1876

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