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Article

The mouse guanylate kinase double mutant E72Q/D103N is a functional adenylate kinase.

Protein engineering - 1 Nov 2001

Stolworthy T S, Black M E

Abstract excerpt

Guanylate kinase catalyzes the phosphorylation of either GMP to GDP or dGMP to dGDP and is an important enzyme in nucleotide metabolic pathways. Because of its essential intracellular role, guanylate kinase is a target for a number of cancer chemotherapeutic agents such as 6-thioguanine and 8-azaguanine and is involved in antiviral drug activation. Guanylate kinase shares a similarity in function and structure to...

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PMID: 11742110
DOI: 10.1093/protein/14.11.903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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