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Article

Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects.

American journal of epidemiology - 15 Oct 2003

Shaw Gary M, Zhu Huiping, Lammer Edward J, Yang Wei, Finnell Richard H

Abstract excerpt

How folate reduces the risks of congenital anomalies is unknown. The authors focused on a gene involved in folate transport-reduced folate carrier-1 gene (RFC1). Using data from a California case-control study (1987-1989 births), the authors investigated whether the risks of orofacial clefts or conotruncal heart defects were influenced by a polymorphism of infant RFC1 or by an interaction between the RFC1 gene...

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Source

Identifiers

PMID: 14561664
DOI: 10.1093/aje/kwg189

Genes

RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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