Article
Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c --> t methylenetetrahydrofolate reductase and 2756a --> g methionine synthase genotypes.
Molecular genetics and metabolism - 1 May 2000
Lucock M, Daskalakis I, Briggs D, Yates Z, Levene M
Abstract excerpt
Periconceptional folate prevents spina bifida although the mechanisms involved are unclear. We present the genotype frequency for the 677 ct methylenetetrahydrofolate reductase (MTHFR) and 2756ag methionine synthase (MetSyn) polymorphisms. Calculated odds ratios (OR) show that neither the homozygous recessive genotype, carriage of the mutant allele, nor frequency of the mutant allele represent significantly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.