Infant C677T mutation in MTHFR, maternal periconceptional vitamin use, and cleft lip.

doi:10.1002/(sici)1096-8628(19981116)80:3<196::aid-ajmg2>3.0.co;2-v

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Article

Infant C677T mutation in MTHFR, maternal periconceptional vitamin use, and cleft lip.

American journal of medical genetics - 16 Nov 1998

Shaw G M, Rozen R, Finnell R H, Todoroff K, Lammer E J

Abstract excerpt

Studies have reported an association between homozygosity for a variant form of the methylenetetrahydrofolate reductase (MTHFR) gene and risk for neural tube defects. Because of MTHFR's involvement with folate metabolism and evidence that maternal use of a multivitamin with folic acid in early pr...

Topics

Case-Control Studies
Cleft Lip
Cytosine
Female
Fertilization
Humans
Infant, Newborn
Methylenetetrahydrofolate Reductase (NADPH2)
Mutation
Oxidoreductases Acting on CH-NH Group Donors
Pregnancy
Thymine
Vitamins

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