Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects.

American journal of medical genetics - 21 May 1999

Christensen B, Arbour L, Tran P, Leclerc D, Sabbaghian N, Platt R, Gilfix B M, Rosenblatt D S, Gravel R A, Forbes P, Rozen R

Abstract excerpt

Folic acid administration to women in the periconceptional period reduces the occurrence of neural tube defects (NTDs) in their offspring. A polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), 677C-->T, is the first genetic risk factor for NTDs in man identified at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Erythrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Homocysteine

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Neural Tube Defects

Share to Oxidoreductases Acting on CH-NH Group Donors

Share to Vitamin B 12

Source

Identifiers

PMID: 10323741
DOI: 10.1002/(sici)1096-8628(19990521)84:2<151::aid-ajmg12>3.0.co;2-t

Genes

MTHFR
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10323741-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects.PMID 10323741Read ↗

Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c --> t methylenetetrahydrofolate reductase and 2756a --> g methionine synthase genotypes.Semantic proximity Read ↗

A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida.Semantic proximity Read ↗

Folate status and neural tube defects.Semantic proximity Read ↗

Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects.Semantic proximity Read ↗

"Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis".Semantic proximity Read ↗

Genetic variation in genes of folate metabolism and neural-tube defect risk.Semantic proximity Read ↗

Altered folate and vitamin B12 metabolism in families with spina bifida offspringSemantic proximity Read ↗

A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group.Semantic proximity Read ↗

Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida.Semantic proximity Read ↗

Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature.Semantic proximity Read ↗

An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy.Semantic proximity Read ↗

Does prenatal screening for 5,10-methylenetetrahydrofolate reductase (MTHFR) mutations in high-risk neural tube defect pregnancies make sense?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.