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Article

Spina bifida and folate-related genes: a study of gene-gene interactions.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2000

de Franchis Raffaella, Botto Lorenzo D, Sebastio Gianfranco, Ricci Roberta, Iolascon Achille, Capra Valeria, Andria Generoso, Mastroiacovo Pierpaolo

Abstract excerpt

PURPOSE: To assess whether interactions of common alleles of two folate genes contribute to spina bifida risk. METHODS: Case-control study, comparing 203 children with spina bifida to 583 controls. RESULTS: Homozygosity for the 677C-T allele of 5,10-methylenetetrahydrofolate reductase (MTHFR) alo...

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Identifiers

PMID: 12180146
DOI: 10.1097/00125817-200205000-00005

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12180146-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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