Article
Role of CCR5, CCR2 and SDF-1 gene polymorphisms in a population of HIV-1 infected individuals.
Journal of biological regulators and homeostatic agents - 1 Jan 2000
Mazzucchelli R, Corvasce S, Violin M, Riva C, Bianchi R, Dehò L, Velleca R, Cibella J, Bada M, Moroni M, Galli M, Balotta C
Abstract excerpt
The finding that in addition to CD4 molecule HIV-1 uses, CCR5 or CXCR4 receptors to enter target cells prompted the research to identify polymorphisms in coreceptor genes affecting disease progression. In this study we analyzed the prevalence of CCR5-delta32, CCR2-641 and SDF1-3'A alleles in a highly selected group of 42 Long-Term Nonprogressors (LTNPs) compared to 112 subjects with a typical course of HIV-1...
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